Complete Information on Degos disease with Treatment and Prevention

Complete Information on Degos disease with Treatment and Prevention

The disease may occur at any age and affects people of all ethnic backgrounds. Degos disease has been associated with systemic diseases. DD has occurred in patients with rheumatoid arthritis, HIV infection, and antiphospholipid antibodies and antiphospholipid syndrome. Viral causes have been implicated. Histopathological findings are wedge-shaped areas of dermal necrosis covered by markedly atrophic malpighian layers and collagen with a smudged appearance. Complications of the disease include peritonitis, intestinal perforation and, less frequently, cerebral infarction.

Some individuals with Degos disease see visual problems or drooping eyelids. Degos disease causes identifiable rind lesions and may include gastrointestinal, visual, and anxious structure problems. Degos disease may impact the gastrointestinal structure, causing abdominal pain, distention, cramps, nausea, vomiting, diarrhoea, or impairment. Some individuals may also experience weakness, shortness of breath, and chest pains. In the skin, degos disease initially manifests with erythematous, pink or red papules. These papules heal to leave scars with pathognomonic, central, porcelain white atrophic centers. These papules usually have a peripheral telangiectatic rim. The outcome of this disease can be fatal although some appear to have a benign form which affects only the skin. There are fewer than fifty living patients at present known worldwide.

The diagnosis of degos disease is usually made based on the specific skin rash. There is no specific laboratory test for degos disease. Antiplatelet drugs (eg, aspirin, dipyridamole) may reduce the number of new lesions in some patients with only skin involvement. There is no specific treatment for degos disease. Other treatments that have been tried without real effect include the following: topical corticosteroids, aspirin and dipyridamole, phenylbutazone, arsenic, phenformin and ethylestrenol, iodohydroxyquinoline, sulphonamides, dextran, corticosteroids, heparin, warfarin, niacin, streptomycin, mycophenolate mofetil, corticotropin, azathioprine, methotrexate, cyclosporine, tacrolimus and clopidogrel. If serious complications such as gastrointestinal bleeding occur, surgery may be necessary. Individuals with Degos disease may benefit from examinations by dermatologists, gastroenterologistsFree Reprint Articles, and ophthalmologists.

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