The Felsher Laboratory in the Department of Medicine/Oncology is looking for a full-time Research Assistant to join our laboratory. This position involves studying anti-cancer therapeutics using in vitro assays, different mouse models of cancer, and patient-derived xenografts.
Our laboratory investigates how oncogenes initiate and sustain tumorigenesis. We have developed model systems whereby we can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice.
In particular, using the tetracycline regulatory system, we have generated a conditional model system for MYC-induce hematopoietic tumors. Using the tet system, we have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation. Thus, even though cancer is a multi-step process, the inactivation of one oncogene can be sufficient to induce tumor regression. Now, we are using these model systems to address three questions:
1. How do oncogenes initiate tumorigenesis?
1. How does oncogene inactivation cause tumor regression?
1. How do tumors escape dependence on oncogenes?
Published at Tue, 24 Nov 2020 01:43:33 +0000