Triple Discordances in Receptor Status During Breast Cancer Local Progression and Metastases …
Adrian Martuszewski,1 Patrycja Paluszkiewicz,1 Mateusz Nowak,1 Krzysztof Szewczyk,2,3 Urszula Staszek-Szewczyk2,4
1Wroclaw Medical University, Wroclaw, Poland; 2Wroclaw Medical University, Department of Oncology, Division of Surgical Oncology, Wroclaw, Poland; 3Wroclaw Regional Comprehensive Cancer Center, 1st Department of Surgical Oncology, Wroclaw, Poland; 4Wroclaw Regional Comprehensive Cancer Center, Department of Brachytherapy, Wroclaw, Poland
Correspondence: Urszula Staszek-Szewczyk
Wroclaw Regional Comprehensive Cancer Center, Pl. Hirszfelda 12, Wroclaw 53-412, Poland
Tel +48 508116999
Fax +48 713619111
Email urszula.staszek-szewczyk@umed.wroc.pl
Abstract: Breast cancer is the most common female malignant neoplasm in Poland and around the world. Precise determination of tumor molecular profile allows application of appropriate anticancer therapy, increasing the chances of recovery. A 28-year-old woman detected a thickening in her left breast. Mammography showed a change measuring 60 mm (radiologically BIRADS 5). The biopsy revealed invasive ductal carcinoma, luminal subtype B, HER2 positive (cT3N1M0). Neoadjuvant chemotherapy was administered and then breast conserving surgery was performed. In postoperative histopathology cancer, biological subtype was evaluated: HER2 positive, nonluminal (ypT2ypN0cM0). Then, postoperative radiotherapy was performed. After 14 months, breast ultrasonography (US) and mammography (MGF) revealed the presence of suspicious changes (BIRADS 4). Tru-cut biopsy confirmed cancer recurrence (luminal subtype B, HER2 negative, ER negative, PgR: 10%, Ki-67: 70%). Despite implemented and modified chemotherapy regimens, local progression occurred. Genetic testing excluded BRCA gene mutation. The patient qualified for radical mastectomy modo Halsted (ypT4bN0cM0). Postoperative microscopic examination revealed triple negative breast invasive carcinoma of no special type. After 22 months, metastatic lesions in lungs and left retrosternal nodes appeared. Due to the limited possibilities of systemic treatment, the patient qualified for stereotactic radiotherapy of tumors in the lungs’ and left retrosternal nodes. Advancement, histological type and molecular profile should be controlled at each stage of the disease, as they may change several times and require modification of therapy.
Keywords: biological subtype, phase disease, personalized treatment
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Published at Mon, 12 Oct 2020 23:03:45 +0000